Special Laboratory of Lasers in Dentistry, Department of Restorative Dentistry, School of Dentistry, University of São Paulo, São Paulo 05508-000, SP, Brazil.
Lasers Med Sci. 2010 May;25(3):397-402. doi: 10.1007/s10103-009-0717-9. Epub 2009 Aug 11.
Alternative treatment for recurrent labial infection by herpes simplex virus (HSV) have been considered. The aim of this study was to evaluate the effectiveness of laser phototherapy in prevention and reduction of severity of labial manifestations of herpes labialis virus. Seventy-one patients, divided into experimental (n = 41) and control (n = 30) groups were followed up for 16 months. Patients in the control group were treated topically with aciclovir and patients in the experimental group were subjected to laser phototherapy (one session per week, 10 weeks): 780 nm, 60 mW, 3.0 J/cm(2) or 4.5 J/cm(2) on healthy (no HSV-1 infection) and affected (with HSV-1 infection) tissues. Patients in the experimental group presented a significant decrease in dimension of herpes labialis lesions (P = 0.013) and inflammatory edema (P = 0.031). The reduction in pain level (P = 0.051) and monthly recurrences (P = 0.076) did not reach statistical significance. This study represents an in vivo indication that this treatment should be further considered as an effective alternative to therapeutic regimens for herpes labialis lesions.
已经考虑了治疗复发性唇疱疹单纯疱疹病毒 (HSV) 的替代方法。本研究旨在评估激光光疗在预防和减少唇疱疹病毒唇疱疹表现严重程度方面的有效性。71 名患者分为实验组（n=41）和对照组（n=30），随访 16 个月。对照组患者局部用阿昔洛韦治疗，实验组患者接受激光光疗（每周一次，10 周）：780nm，60mW，3.0J/cm(2)或 4.5J/cm(2)用于健康（无 HSV-1 感染）和受影响（有 HSV-1 感染）组织。实验组患者唇疱疹病变的尺寸（P=0.013）和炎症性水肿（P=0.031）明显减小。疼痛程度（P=0.051）和每月复发次数（P=0.076）的减少没有达到统计学意义。本研究代表了一种体内迹象，表明这种治疗方法应进一步被视为治疗唇疱疹病变的有效替代方案。
