Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
Nano Lett. 2011 Dec 14;11(12):5391-5. doi: 10.1021/nl2030213. Epub 2011 Nov 7.
Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.
细胞内吞作用对于药物输送和纳米医学至关重要。然而，被动内吞作用（即非 ATP 驱动）发生的条件还不是很清楚。我们报告了不同大小、形状、覆盖度和膜结合强度的配体包覆纳米颗粒的被动摄取的 MD 模拟。我们发现，对于类球柱形颗粒，被动内吞作用的效率高于球形颗粒，而对于具有锐利边缘的颗粒，内吞作用受到抑制。
