性激素结合球蛋白与 2 型糖尿病。
Sex hormone-binding globulin and type 2 diabetes mellitus.
机构信息
Department of Pediatrics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
出版信息
Trends Endocrinol Metab. 2012 Jan;23(1):32-40. doi: 10.1016/j.tem.2011.09.005. Epub 2011 Nov 1.
Abstract
Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic and environmental factors that potentially contribute to the pathophysiology of type 2 diabetes mellitus (T2DM). In addition to epidemiologic studies demonstrating a consistent relationship between decreased levels of serum SHBG and incident T2DM, recent genetic studies also reveal that transmission of specific polymorphisms in the SHBG gene influence the risk of T2DM. At the molecular level, the multiple interactions between SHBG and its receptors in various target tissues suggest physiologic roles for SHBG that are more complex than the simple transport of sex hormones in serum. Taken together, these data provide support for an expanded role of SHBG in the pathophysiology of insulin resistance and T2DM.
摘要
性激素结合球蛋白（SHBG）已成为多种可能导致 2 型糖尿病（T2DM）病理生理学的遗传和环境因素之一。除了流行病学研究表明血清 SHBG 水平降低与 T2DM 发病之间存在一致关系外，最近的遗传研究还表明，SHBG 基因中特定多态性的传递会影响 T2DM 的发病风险。在分子水平上，SHBG 与其在各种靶组织中的受体之间的多种相互作用表明，SHBG 的生理作用比在血清中简单地运输性激素更为复杂。综上所述，这些数据为 SHBG 在胰岛素抵抗和 T2DM 的病理生理学中发挥更广泛的作用提供了支持。
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