Department of Neonatology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
J Pediatr. 2012 Apr;160(4):578-583.e2. doi: 10.1016/j.jpeds.2011.09.025. Epub 2011 Nov 1.
To analyze risk factors for bronchopulmonary dysplasia (BPD) or death according to the condition leading to extremely preterm birth, preterm labor, or vascular disorders.
Retrospective study of all premature births before 28 weeks of gestation in a single Level III institution. Mother/infants were attributed to the "preterm labor" or "vascular disorder" group according to the condition leading to delivery. Characteristics and outcomes were compared between groups. Independent risk factors for BPD or the composite outcome "BPD or death" were identified within each group.
Three hundred ninety-six infants from 349 pregnancies were characterized for perinatal characteristics. BPD was significantly more frequent in the vascular disease group than in the preterm labor group (29% vs 11%, P < .01). Independent risk factors of BPD were a low gestational age in the preterm labor group and severe growth restriction in the vascular disease group.
Classification of preterm birth according to the condition leading to delivery might help to reduce confounding of risk factors for BPD. Intrauterine vascular disorders are significantly associated with BPD.
根据导致极早产、早产临产或血管病变的病因，分析支气管肺发育不良（BPD）或死亡的危险因素。
对单家三级医疗机构所有 28 周前早产儿进行的回顾性研究。根据分娩病因，将母亲/婴儿归入“早产临产”或“血管病变”组。比较组间特征和结局。在每个组内，确定 BPD 或复合结局“BPD 或死亡”的独立危险因素。
对 349 例妊娠的 396 例婴儿进行了围生期特征描述。血管疾病组的 BPD 发生率显著高于早产临产组（29% vs 11%，P<.01）。早产临产组的独立危险因素是低胎龄，而血管疾病组的独立危险因素是严重生长受限。
根据导致分娩的病因对早产进行分类，可能有助于减少 BPD 危险因素的混杂。宫内血管病变与 BPD 显著相关。
