Neonatal Intensive Care Unit, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Am J Obstet Gynecol. 2013 Feb;208(2):115.e1-9. doi: 10.1016/j.ajog.2012.11.026. Epub 2012 Nov 21.
We sought to assess the independent effect of perinatal factors on the risk for bronchopulmonary dysplasia (BPD) in very-low-birthweight infants.
This was a population-based observational study. Data were prospectively collected by the Israel Neonatal Network. Multivariable analyses identified independent risk factors for BPD.
Of 12,139 infants surviving to a postmenstrual age of 36 weeks, 1663 (13.7%) developed BPD. BPD was independently associated with young maternal age (odds ratio [OR], 1.53), maternal hypertensive disorders (OR, 1.28), antepartum hemorrhage (OR, 1.26), male gender (OR, 1.41), non-Jewish ethnicity (OR, 1.23), birth defects (OR, 1.94), small for gestational age (GA) (OR, 2.65), and delivery room resuscitation (OR, 1.86). Stratified analysis by GA groups showed that postdelivery resuscitation had a more pronounced effect with increasing maturity.
Perinatal factors and pregnancy complications were independently associated with development of BPD in very-low-birthweight infants. Most risk factors identified were consistent within GA groups.
我们旨在评估围产期因素对极低出生体重儿支气管肺发育不良（BPD）风险的独立影响。
这是一项基于人群的观察性研究。以色列新生儿网络前瞻性收集数据。多变量分析确定了 BPD 的独立危险因素。
在存活至 36 周校正胎龄的 12139 名婴儿中，1663 名（13.7%）发生 BPD。BPD 与母亲年龄较小（比值比 [OR]，1.53）、母亲高血压疾病（OR，1.28）、产前出血（OR，1.26）、男性性别（OR，1.41）、非犹太教种族（OR，1.23）、出生缺陷（OR，1.94）、小于胎龄儿（OR，2.65）和产房复苏（OR，1.86）独立相关。按胎龄分组的分层分析表明，随着成熟度的增加，分娩后复苏的影响更为明显。
围产期因素和妊娠并发症与极低出生体重儿 BPD 的发生独立相关。大多数确定的危险因素在 GA 组内是一致的。
