Department of Radiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
J Pediatr. 2012 Apr;160(4):604-609.e1. doi: 10.1016/j.jpeds.2011.09.035. Epub 2011 Nov 1.
To characterize the changes in brown adipose tissue (BAT) occurring during puberty in boys and girls.
We examined the prevalence and the volume of BAT at different stages of sexual development in 73 pediatric patients who underwent positron emission tomography (PET)/computed tomography (CT) studies.
Of the 73 patients studied, 43 (59%) had BAT depicted on PET/CT. The presence of BAT was detected significantly less frequently on PET/CT in prepubertal subjects (Tanner stage 1) than in pubertal subjects (Tanner stages 2-5) (15% vs 75%). BAT volume also increased during puberty, with a significantly greater magnitude of the increase in the final 2 stages of puberty (Tanner stages 4 and 5) than in earlier stages (Tanner stages 1-3) (boys: 499 ± 246 vs 50 ± 36, P < .0001; girls: 286 ± 139 vs 36 ± 29, P = .024). Changes in BAT volume were also significantly greater in boys than in girls (P = .004) and were closely related to muscle volume (r = 0.52, P < .01 for boys; r = 0.64, P < .01 for girls).
The presence and volume of BAT increase rapidly during puberty. Metabolic and hormonal events related to the achievement of sexual maturity are likely responsible for this increase.
描述男孩和女孩青春期棕色脂肪组织 (BAT) 的变化特征。
我们检查了 73 名接受正电子发射断层扫描 (PET)/计算机断层扫描 (CT) 研究的儿科患者在不同性发育阶段 BAT 的患病率和体积。
在研究的 73 名患者中，43 名（59%）在 PET/CT 上显示有 BAT。在青春期前（Tanner 分期 1）与青春期（Tanner 分期 2-5）患者相比，PET/CT 上检测到 BAT 的存在频率明显较低（15%比 75%）。BAT 体积也在青春期增加，在青春期的最后两个阶段（Tanner 分期 4 和 5）比早期阶段（Tanner 分期 1-3）增加幅度更大（男孩：499 ± 246 比 50 ± 36，P <.0001；女孩：286 ± 139 比 36 ± 29，P =.024）。BAT 体积的变化在男孩中也明显大于女孩（P =.004），并且与肌肉体积密切相关（男孩 r = 0.52，P <.01；女孩 r = 0.64，P <.01）。
BAT 的存在和体积在青春期迅速增加。与达到性成熟相关的代谢和激素事件可能是导致这种增加的原因。
