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酿酒酵母的DNA损伤诱导基因DIN1编码核糖核苷酸还原酶的一个调节亚基,且与RNR3相同。

The DNA damage-inducible gene DIN1 of Saccharomyces cerevisiae encodes a regulatory subunit of ribonucleotide reductase and is identical to RNR3.

作者信息

Yagle K, McEntee K

机构信息

Laboratory of Biomedical and Environmental Sciences, UCLA School of Medicine 90024-1786.

出版信息

Mol Cell Biol. 1990 Oct;10(10):5553-7. doi: 10.1128/mcb.10.10.5553-5557.1990.

Abstract

The sequence of the DIN1 gene of Saccharomyces cerevisiae is identical to RNR3, a gene encoding a DNA damage-inducible regulatory subunit of ribonucleotide reductase. Two sequence elements located upstream of DIN1 (RNR3) are homologous to putative DNA damage regulatory elements in the promoter of the reductase catalytic subunit gene, RNR2. The transcript start sites for DIN1(RNR3) have been localized, and induction by different agents has been compared with other DNA damage-regulated genes.

摘要

酿酒酵母的DIN1基因序列与RNR3相同,RNR3是一个编码核糖核苷酸还原酶的DNA损伤诱导调节亚基的基因。位于DIN1(RNR3)上游的两个序列元件与还原酶催化亚基基因RNR2启动子中假定的DNA损伤调节元件同源。DIN1(RNR3)的转录起始位点已被定位,并且已将不同试剂的诱导作用与其他DNA损伤调节基因进行了比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23df/361273/a020b9ca2c1f/molcellb00046-0540-a.jpg

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