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酿酒酵母的DNA损伤诱导基因DIN1编码核糖核苷酸还原酶的一个调节亚基，且与RNR3相同。

The DNA damage-inducible gene DIN1 of Saccharomyces cerevisiae encodes a regulatory subunit of ribonucleotide reductase and is identical to RNR3.

作者信息

Yagle K, McEntee K

机构信息

Laboratory of Biomedical and Environmental Sciences, UCLA School of Medicine 90024-1786.

出版信息

Mol Cell Biol. 1990 Oct;10(10):5553-7. doi: 10.1128/mcb.10.10.5553-5557.1990.

DOI:10.1128/mcb.10.10.5553-5557.1990
PMID:2204819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC361273/
Abstract

The sequence of the DIN1 gene of Saccharomyces cerevisiae is identical to RNR3, a gene encoding a DNA damage-inducible regulatory subunit of ribonucleotide reductase. Two sequence elements located upstream of DIN1 (RNR3) are homologous to putative DNA damage regulatory elements in the promoter of the reductase catalytic subunit gene, RNR2. The transcript start sites for DIN1(RNR3) have been localized, and induction by different agents has been compared with other DNA damage-regulated genes.

摘要

酿酒酵母的DIN1基因序列与RNR3相同，RNR3是一个编码核糖核苷酸还原酶的DNA损伤诱导调节亚基的基因。位于DIN1（RNR3）上游的两个序列元件与还原酶催化亚基基因RNR2启动子中假定的DNA损伤调节元件同源。DIN1（RNR3）的转录起始位点已被定位，并且已将不同试剂的诱导作用与其他DNA损伤调节基因进行了比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23df/361273/eefe6fc91007/molcellb00046-0541-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23df/361273/a020b9ca2c1f/molcellb00046-0540-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23df/361273/eefe6fc91007/molcellb00046-0541-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23df/361273/a020b9ca2c1f/molcellb00046-0540-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23df/361273/eefe6fc91007/molcellb00046-0541-a.jpg

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1
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本文引用的文献

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Cloning regulated yeast genes from a pool of lacZ fusions.从一组乳糖操纵子融合体中克隆受调控的酵母基因。
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Nucleoside 5'-diphosphates as effectors of mammalian ribonucleotide reductase.核苷5'-二磷酸作为哺乳动物核糖核苷酸还原酶的效应物。
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Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint.高度诱变和严重失衡的 dNTP 池可以逃避 S 期检查点的检测。
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The WTM genes in budding yeast amplify expression of the stress-inducible gene RNR3.芽殖酵母中的WTM基因增强应激诱导基因RNR3的表达。
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Why multiple small subunits (Y2 and Y4) for yeast ribonucleotide reductase? Toward understanding the role of Y4.酵母核糖核苷酸还原酶为何有多个小亚基（Y2和Y4）？探索Y4的作用。
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10067-72. doi: 10.1073/pnas.181336498.
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Derepression of DNA damage-regulated genes requires yeast TAF(II)s.DNA损伤调控基因的去抑制需要酵母TAF（II）蛋白。
EMBO J. 2000 Aug 1;19(15):4091-100. doi: 10.1093/emboj/19.15.4091.
8
Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.酵母MEC和RAD检查点基因在DNA损伤后转录诱导中的不同作用及其功能意义
Mol Biol Cell. 1996 May;7(5):703-18. doi: 10.1091/mbc.7.5.703.
9
Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae.Msn2p是一种锌指DNA结合蛋白，是酿酒酵母中多重应激反应的转录激活因子。
Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5777-82. doi: 10.1073/pnas.93.12.5777.
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Regulation of SNM1, an inducible Saccharomyces cerevisiae gene required for repair of DNA cross-links.酿酒酵母中一种参与DNA交联修复的可诱导基因SNM1的调控。
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J Biol Chem. 1985 Oct 5;260(22):12001-7.
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Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells.
J Biol Chem. 1985 Mar 10;260(5):2737-41.
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Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate.酵母核糖核苷酸还原酶小亚基基因的鉴定及其对甲磺酸甲酯的诱导性
Mol Cell Biol. 1987 Oct;7(10):3673-7. doi: 10.1128/mcb.7.10.3673-3677.1987.
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Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability.酿酒酵母中核糖核苷酸还原酶小亚基编码基因的鉴定与分离：有丝分裂活力所需的DNA损伤诱导基因。
Mol Cell Biol. 1987 Aug;7(8):2783-93. doi: 10.1128/mcb.7.8.2783-2793.1987.
7
DNA damage and heat shock dually regulate genes in Saccharomyces cerevisiae.DNA损伤和热休克双重调控酿酒酵母中的基因。
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9
Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it.核糖核苷酸还原酶2（RNR2）DNA损伤反应元件的鉴定及四种不同细胞因子与之结合的证据。
Mol Cell Biol. 1989 Dec;9(12):5373-86. doi: 10.1128/mcb.9.12.5373-5386.1989.
10
Upstream regulatory sequences of the yeast RNR2 gene include a repression sequence and an activation site that binds the RAP1 protein.
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