Thurnham D I, Singkamani R, Kaewichit R, Wongworapat K
Clinical Investigation Unit, Dudley Road Hospital, Birmingham.
Br J Nutr. 1990 Jul;64(1):257-71. doi: 10.1079/bjn19900027.
Measurement of peroxyl-radical trapping capacity (TRAP) were made in plasma from patients with malaria from a rural and an urban Thai community. The results were compared with those from control subjects living in the same areas and chosen to match the patients closely. Measurements were also made of various antioxidants including nutritional indices vitamin C and alpha-tocopherol and the non-nutritional indices urate and protein-sulphydryl. Parasite counts, temperature on examination and the duration of illness were recorded together with measurements of plasma caeruloplasmin (EC 1.16.3.1), retinol and malondialdehyde (MDA). In general, most measurements made in the villagers were lower than those in the comparable urban groups. The exceptions were caeruloplasmin and MDA when the latter was expressed as MDA:cholesterol ratio. TRAP values were extremely low in 50% of the villagers and 25% of the urban patients with malaria and these results correlated with retinol and vitamin C and inversely with malonaldehyde. The results suggested that low TRAP values are associated with lipid peroxidation and that vitamin C and possibly retinol may be destroyed by the oxidative conditions present in the plasma in this disease.
对来自泰国一个农村和一个城市社区的疟疾患者血浆进行了过氧自由基捕获能力（TRAP）的测定。将结果与来自生活在相同地区且经过精心挑选以与患者密切匹配的对照受试者的结果进行比较。还对包括营养指标维生素C和α-生育酚以及非营养指标尿酸盐和蛋白质巯基在内的各种抗氧化剂进行了测定。记录了寄生虫计数、检查时的体温和病程，同时测定了血浆铜蓝蛋白（EC 1.16.3.1）、视黄醇和丙二醛（MDA）。总体而言，在村民中进行的大多数测量结果低于可比的城市组。例外情况是铜蓝蛋白和MDA（当后者表示为MDA：胆固醇比率时）。50%的村民和25%的城市疟疾患者的TRAP值极低，这些结果与视黄醇和维生素C相关，与丙二醛呈负相关。结果表明，低TRAP值与脂质过氧化有关，并且维生素C以及可能的视黄醇可能在这种疾病的血浆氧化条件下被破坏。
