Ginsberg M D, Reivich M, Giandomenico A, Greenberg J H
Neurology. 1977 Nov;27(11):1042-8. doi: 10.1212/wnl.27.11.1042.
By means of an autoradiographic technique employing 14C-2-deoxyglucose, abnormalities of local brain glucose utilization were studied 90 minutes following occlusion of the left middle cerebral and common carotid arteries in a series of pentobarbital-anesthetized cats. Sham-insulted control animals exhibited a normal pattern of regional glucose utilization. In animals with vascular occlusion, a zone of greatly suppressed glucose utilization occupied the caudate nucleus of the ischemic hemisphere, with variable extension, and was surrounded by a narrow rim of increased local brain glucose utilization, suggesting the occurrence of enhanced anaerobic glycolysis in the latter zones. The cerebral cortex, which was less constantly affected, showed alternating regions of increased and decreased glucose utilization. Quantitation of local brain glucose utilization values from the contralateral nonischemic hemisphere revealed a mild suppression of cortical glucose utilization relative to the control animals. This may be the metabolic equivalent of diaschisis.
通过采用14C-2-脱氧葡萄糖的放射自显影技术，在一系列戊巴比妥麻醉的猫中，于左大脑中动脉和颈总动脉闭塞90分钟后研究局部脑葡萄糖利用异常情况。假损伤对照动物表现出正常的区域葡萄糖利用模式。在血管闭塞的动物中，一个葡萄糖利用被极大抑制的区域占据了缺血半球的尾状核，其范围不一，并被局部脑葡萄糖利用增加的狭窄边缘所包围，提示在后者区域发生了增强的无氧糖酵解。受影响不太恒定的大脑皮层显示出葡萄糖利用增加和减少的交替区域。对来自对侧非缺血半球的局部脑葡萄糖利用值进行定量分析发现，相对于对照动物，皮层葡萄糖利用有轻度抑制。这可能是交叉性神经机能联系不能的代谢等效物。
