Elsner P, Wilhelm D, Maibach H I
Department of Dermatology, School of Medicine, University of California, San Francisco.
Contact Dermatitis. 1990 Jul;23(1):20-6. doi: 10.1111/j.1600-0536.1990.tb00078.x.
Transepidermal water loss (TEWL), capacitance, pH, blood flow and color reflectance were evaluated for quantifying the irritant response of vulvar and forearm skin to 3% sodium lauryl sulfate in 9 healthy premenopausal women. TEWL, capacitance, pH, blood flow, and all parameters of color reflectance changed significantly in forearm irritant dermatitis. In vulvar irritant dermatitis, however, significant changes were observed only for blood flow and the color reflectance parameters a* and b*. Using the combination of TEWL, capacitance and blood flow, forearm irritant dermatitis was detected with a sensitivity of 84% and a specificity of 100%. In this study, the best combination of parameters to detect vulvar irritant dermatitis was pH, blood flow, a* and b*, which had a sensitivity of 78% and a specificity of 75%. It is concluded that available bioengineering techniques are less suitable to quantify irritant dermatitis in the vulva than in the forearm.
对9名健康的绝经前女性，评估经表皮水分流失（TEWL）、电容、pH值、血流和颜色反射率，以量化外阴和前臂皮肤对3%月桂醇硫酸酯钠的刺激反应。前臂刺激性皮炎中，TEWL、电容、pH值、血流以及颜色反射率的所有参数均发生显著变化。然而，在外阴刺激性皮炎中，仅观察到血流以及颜色反射率参数a和b有显著变化。采用TEWL、电容和血流相结合的方法，检测前臂刺激性皮炎的灵敏度为84%，特异性为100%。在本研究中，检测外阴刺激性皮炎的最佳参数组合为pH值、血流、a和b，其灵敏度为78%，特异性为75%。得出的结论是，现有的生物工程技术对外阴刺激性皮炎的量化不如对前臂刺激性皮炎的量化适用。
