Elsner P, Wilhelm D, Maibach H I
Department of Dermatology, School of Medicine, University of California, San Francisco.
J Reprod Med. 1990 Nov;35(11):1035-9.
The reactivity of forearm and vulvar skin to sodium lauryl sulfate (SLS) was studied in two groups of 20 healthy women each, 10 before and 10 after menopause. Vulvar skin was less reactive to SLS in both low and high concentrations than was forearm skin. Transepidermal water loss measurement did not seem to be an indicator of irritant dermatitis in vulvar skin. Capacitance measurements, reflecting changes in skin hydration, seemed to be more suitable for monitoring vulvar irritant dermatitis. Age-related differences in irritant reaction were more apparent in low-grade irritant dermatitis induced by low concentrations of SLS than in intense reactions to higher SLS concentrations.
对两组各20名健康女性（每组中10名绝经前女性和10名绝经后女性）的前臂和外阴皮肤对月桂醇硫酸酯钠（SLS）的反应性进行了研究。在低浓度和高浓度下，外阴皮肤对SLS的反应性均低于前臂皮肤。经表皮水分流失测量似乎不是外阴皮肤刺激性皮炎的指标。反映皮肤水合作用变化的电容测量似乎更适合监测外阴刺激性皮炎。与年龄相关的刺激反应差异在低浓度SLS引起的轻度刺激性皮炎中比在对较高SLS浓度的强烈反应中更明显。
