Elsner P, Wilhelm D, Maibach H I
Department of Dermatology, School of Medicine, University of California, San Francisco.
J Am Acad Dermatol. 1990 Oct;23(4 Pt 1):648-52. doi: 10.1016/0190-9622(90)70268-m.
Reactivity of the skin of the forearm and labia majora to three concentrations (2%, 3%, 5%) of sodium lauryl sulfate was studied in 20 healthy women, 10 premenopausal and 10 postmenopausal. Patches with the irritant were applied on day 0 for 24 hours. Skin changes were monitored by visual scoring and by the measurement of transepidermal water loss and capacitance as indicators of stratum corneum hydration on days 2, 3, 7, and 10. In forearm skin, irritant dermatitis developed in the majority of subjects as indicated by visual scoring and increase of transepidermal water loss. These changes were not significantly dependent on the concentration of sodium lauryl sulfate. In labia majora skin, irritant dermatitis developed in 50% of the women as determined by visual scoring; however, because of the pigmentation, visual scoring readings were less reliable in labia majora skin. Transepidermal water loss did not increase, but a significant and immediate decrease in capacitance was noted in labia majora skin. In forearm skin, postmenopausal women reacted less frequently and more slowly to sodium lauryl sulfate than premenopausal women whereas no age-related differences were observed in reaction of the vulvar skin. It is concluded that labia majora skin is not more reactive to sodium lauryl sulfate than forearm skin and that capacitance is more sensitive than transepidermal water loss in monitoring vulvar irritant dermatitis. Age-related differences in irritant reaction are apparent in the forearm, but not the vulva.
在20名健康女性（10名绝经前女性和10名绝经后女性）中，研究了前臂皮肤和大阴唇皮肤对三种浓度（2%、3%、5%）月桂醇硫酸酯钠的反应性。在第0天将含有刺激性物质的贴片贴敷24小时。在第2、3、7和10天，通过视觉评分以及测量经表皮水分流失和电容作为角质层水合作用指标来监测皮肤变化。在前臂皮肤中，如视觉评分和经表皮水分流失增加所示，大多数受试者出现刺激性皮炎。这些变化与月桂醇硫酸酯钠的浓度没有显著相关性。在大阴唇皮肤中，通过视觉评分确定50%的女性出现刺激性皮炎；然而，由于色素沉着，大阴唇皮肤的视觉评分读数不太可靠。经表皮水分流失没有增加，但大阴唇皮肤的电容出现显著且即时的下降。在前臂皮肤中，绝经后女性对月桂醇硫酸酯钠的反应比绝经前女性更不频繁且更缓慢，而在外阴皮肤反应中未观察到与年龄相关的差异。结论是，大阴唇皮肤对月桂醇硫酸酯钠的反应性并不比前臂皮肤更高，并且在监测外阴刺激性皮炎时，电容比经表皮水分流失更敏感。刺激性反应的年龄相关差异在前臂明显，但在外阴不明显。
