Freeman S, Maibach H
Skin and Cancer Foundation, University of New South Wales, Sydney, Australia.
J Am Acad Dermatol. 1988 Sep;19(3):496-502. doi: 10.1016/s0190-9622(88)70204-2.
Eleven subjects received patch tests with 2% sodium lauryl sulfate on a total of 34 anatomic sites. The irritant effect was monitored by visual means, laser Doppler velocimetry, and measurement of transepidermal water loss. After 1 week, repeat patch tests with 2% sodium lauryl sulfate were performed on the same site, and the effect was monitored as before. Although the skin had returned to normal or near normal before the repeat patch test, an augmented response to irritation was generally seen after the repeat patch test, particularly in transepidermal water loss, which showed an augmented response in 29 of the 34 anatomic sites. The clinical implications regarding the healing of contact irritant dermatitis are discussed.
11名受试者在总共34个解剖部位接受了2%月桂醇硫酸酯钠的斑贴试验。通过视觉观察、激光多普勒血流仪以及经表皮水分流失测量来监测刺激效果。1周后，在同一部位再次进行2%月桂醇硫酸酯钠的斑贴试验，并像之前一样监测效果。尽管在重复斑贴试验前皮肤已恢复正常或接近正常，但重复斑贴试验后通常会出现对刺激的增强反应，尤其是经表皮水分流失方面，在34个解剖部位中有29个部位出现了增强反应。文中讨论了关于接触性刺激性皮炎愈合的临床意义。
