Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, TAC S441-C, New Haven, CT 06519, USA.
Clin Chest Med. 2011 Dec;32(4):605-44. doi: 10.1016/j.ccm.2011.09.001.
Lung cancer is the leading cause of cancer death in the United States and around the world. A vast majority of lung cancer deaths are attributable to cigarette smoking, and curbing the rates of cigarette smoking is imperative. Understanding the epidemiology and causal factors of lung cancer can provide additional foundation for disease prevention. This article focuses on modifiable risk factors, including tobacco smoking, occupational carcinogens, diet, and ionizing radiation. It also discusses briefly the molecular and genetic aspects of lung carcinogenesis.
肺癌是美国和全球癌症死亡的主要原因。绝大多数肺癌死亡归因于吸烟,遏制吸烟率势在必行。了解肺癌的流行病学和因果因素可为疾病预防提供更多依据。本文重点介绍可改变的危险因素,包括烟草吸烟、职业致癌物、饮食和电离辐射。本文还简要讨论了肺癌发生的分子和遗传方面。