Kim Se-Kwon, Karadeniz Fatih
Department of Chemistry, Pukyong National University, Busan, Republic of Korea.
Adv Food Nutr Res. 2011;64:255-65. doi: 10.1016/B978-0-12-387669-0.00020-X.
In recent years, elucidation of novel bioactive substances from different marine organisms is gaining importance rapidly not only from the research and publications but also from controlled clinical studies of natural product-derived substances. They offer important leads for the development of antiviral drugs against viral infections caused by human immunodeficiency virus type 1 (HIV-1). Regarding this issue, numerous anti-HIV-1 therapeutic agents from marine resources have been reported for their potential medicine/medical application as novel functional ingredients in anti-HIV therapy. In detail, marine macroalgae have attracted much of attention as a reliable source for potential anti-HIV compounds. Up to date, several types of compounds such as tannins, polysaccharides, lectins, and derivatives have been isolated, identified, and reported to possess significant anti-HIV-1 activity.
近年来，从不同海洋生物中阐明新型生物活性物质不仅在研究和出版物方面迅速变得重要，而且在天然产物衍生物质的对照临床研究中也日益重要。它们为开发针对由1型人类免疫缺陷病毒（HIV-1）引起的病毒感染的抗病毒药物提供了重要线索。关于这个问题，已经报道了许多来自海洋资源的抗HIV-1治疗剂作为抗HIV治疗中新型功能成分的潜在医学应用。详细地说，海洋大型藻类作为潜在抗HIV化合物的可靠来源已引起了广泛关注。到目前为止，已经分离、鉴定并报道了几种类型的化合物，如单宁、多糖、凝集素及其衍生物具有显著的抗HIV-1活性。
