Department of Neurology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Neurol Sci. 2012 Mar 15;314(1-2):102-3. doi: 10.1016/j.jns.2011.10.013. Epub 2011 Nov 5.
Viral infections may induce exacerbation of multiple sclerosis (MS), and attempts should be made to prevent them in MS patients by means of vaccines, but immunization is considered to possibly trigger autoimmune disease activity.
We studied the safety and patient compliance of seasonal influenza and H1N1v influenza vaccines.
Clinical data on 101 consecutive patients with MS who participated in the study conducted between December, 2009 and February, 2010 were retrieved from the patients' charts. They all filled in a questionnaire on demographics, clinical symptoms and, when applicable, date of being vaccinated for seasonal influenza and/or H1N1v influenza.
Five of the 49 vaccinated patients reported side effects of fever or flu-like symptoms associated with the administration of either of the vaccines: there were no complications or need for hospitalization. No patient reported any new neurological symptoms following the use of either vaccine. It emerged that many MS patients did not receive at least one of the vaccines, and that a substantial number of physicians were unsure of how to advise on vaccinations.
Our results are intended to help reassure patients with MS and their physicians about the safety of seasonal influenza and H1N1v influenza vaccines.
病毒感染可能会诱发多发性硬化症（MS）恶化，因此应通过疫苗来预防 MS 患者的病毒感染，但免疫接种被认为可能会引发自身免疫性疾病活动。
我们研究了季节性流感和 H1N1v 流感疫苗的安全性和患者依从性。
从 2009 年 12 月至 2010 年 2 月期间参与研究的 101 例连续 MS 患者的病历中检索到临床数据。他们都填写了一份关于人口统计学、临床症状以及（如适用）季节性流感和/或 H1N1v 流感疫苗接种日期的问卷。
在接种疫苗的 49 名患者中，有 5 名报告了与接种任何一种疫苗相关的发热或流感样症状的副作用：没有发生并发症或需要住院治疗。没有患者报告在使用任何一种疫苗后出现新的神经症状。结果表明，许多 MS 患者未接种至少一种疫苗，而且相当数量的医生不确定如何就疫苗接种提供建议。
我们的研究结果旨在帮助 MS 患者及其医生放心使用季节性流感和 H1N1v 流感疫苗的安全性。
