Jackson C W, Steward S A, Hutson N K, McDonald T P
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
Int J Cell Cloning. 1990 Jul;8(4):260-6. doi: 10.1002/stem.5530080410.
The DNA content of normal megakaryocytes usually ranges from 8N to 64N, with 16N as the modal DNA content. The frequency of cells at each DNA content can be altered by experimental induction of thrombocytopenia, thrombocytosis or marrow ablation, and in various disease states; however, the mechanisms and regulation involved in the process of polyploidization remain obscure. This discussion will focus on genetic and physiologic variations in megakaryocyte DNA content distributions. The genetic variations are those we have observed among mouse strains, with the most pronounced present in several C3H substrains in which the modal megakaryocyte DNA content is 32N, rather than 16N. The physiologic variation reported here is a shift to the right in megakaryocyte DNA content distributions during late pregnancy in the rat.
正常巨核细胞的DNA含量通常在8N至64N之间，其中16N为DNA含量众数。通过实验诱导血小板减少、血小板增多或骨髓消融，以及在各种疾病状态下，每个DNA含量的细胞频率会发生改变；然而，多倍体化过程中涉及的机制和调控仍不清楚。本讨论将聚焦于巨核细胞DNA含量分布的遗传和生理变异。遗传变异是我们在小鼠品系中观察到的，最显著的是在几个C3H亚系中，其中巨核细胞DNA含量众数为32N，而非16N。此处报道的生理变异是大鼠妊娠晚期巨核细胞DNA含量分布向右偏移。
