Lin P-K, Chang J-F, Wei C-H, Tsao P H, Fann W S, Chen Y-L
Institute of Physics, Academia Sinica, Taipei, 11529, Taiwan, Republic of China.
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Sep;84(3 Pt 1):031917. doi: 10.1103/PhysRevE.84.031917. Epub 2011 Sep 19.
We performed experiments and simulations to investigate the influence of hydrodynamic interaction on the diffusion dynamics of circular and linear λ-DNA confined in nanoslits. Contrary to the common assumption that intrachain hydrodynamic interaction (HI) is completely screened when polymers are confined in channels with height h smaller than the radius of gyration R(g), it is found that the HI is partially screened and approaches complete screening only for R(g)≪h. For λ-DNA, the HI becomes nearly completely screened only when the channel height is smaller than the Kuhn length. In addition, the dynamics of linear and circular λ-DNA in very strong confinement is shown to be independent of the chain topology.
我们进行了实验和模拟，以研究流体动力相互作用对限制在纳米狭缝中的环状和线性λ-DNA扩散动力学的影响。与聚合物被限制在高度h小于回转半径R(g)的通道中时链内流体动力相互作用(HI)被完全屏蔽的普遍假设相反，我们发现HI只是部分被屏蔽，并且仅在R(g)≪h时才接近完全屏蔽。对于λ-DNA，仅当通道高度小于库恩长度时，HI才几乎完全被屏蔽。此外，在极强限制条件下线性和环状λ-DNA的动力学表现出与链拓扑结构无关。
