Division of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, PR China.
Chem Phys Lipids. 2012 Jan;165(1):32-7. doi: 10.1016/j.chemphyslip.2011.10.005. Epub 2011 Oct 25.
High-density lipoprotein (HDL) particles are anti-atherosclerotic, by virtue of their functions in reverse cholesterol transportation, anti-inflammation and anti-oxidation. However, recent studies have cast doubt on the cardio-protective role of HDL. Structural modification and composition alteration of HDL due to chronic inflammation and acute phase responses may result in loss of normal biological function and even convert HDL into a pro-inflammatory and pro-oxidative agent. Therefore, the assessment of dysfunctional HDL has become a novel target to investigate the association between HDL and coronary artery disease risk. This review article summarizes the laboratory assessment of dysfunctional HDL.
高密度脂蛋白（HDL）颗粒具有抗动脉粥样硬化作用，这得益于其在胆固醇逆转运、抗炎和抗氧化方面的功能。然而，最近的研究对 HDL 的心脏保护作用提出了质疑。由于慢性炎症和急性期反应，HDL 的结构修饰和组成改变可能导致其正常生物学功能丧失，甚至使 HDL 转变为促炎和促氧化剂。因此，对功能失调的 HDL 的评估已成为研究 HDL 与冠状动脉疾病风险之间关系的新靶点。本文综述了功能失调的 HDL 的实验室评估方法。
