Fürst C J, Lundell M, Holm L E
Department of General Oncology, Karolinska Hospital, Stockholm, Sweden.
Acta Oncol. 1990;29(5):557-62. doi: 10.3109/02841869009090050.
A case-control study was conducted to investigate the possible association between absorbed dose and cancer risk in a cohort of 14,647 individuals (33% males and 67% females) less than 18 months old and irradiated for skin hemangioma between 1920 and 1959. The cases consisted of 56 breast cancers (in 55 patients), 14 thyroid cancers, 16 brain tumors and 8 tumors of bone and soft tissues. Four controls were matched to each case. They were matched for sex, age at treatment, treatment modality and treatment year. Absorbed doses were categorized in three exposure groups, less than 0.1 Gy, 0.1-0.4 Gy, and greater than or equal to 0.5 Gy, and odds ratios (OR) were estimated with the lowest exposure group as reference. A statistically significant positive dose-response relationship was found for thyroid cancer (OR: 1.0; 4.8; 4.3) and for tumors of bone and soft tissues (OR: 1.0; 1.6; 19.5). For breast cancer and brain tumors no significant dose-response relationship could be found. The median absorbed dose in the tumor sites among the cases of thyroid cancer, tumors of bone and soft tissues, breast cancer and brain tumors was 0.2 Gy, 0.3 Gy, 0.03 Gy and 0.04 Gy respectively. The dose was probably too low to detect any dose-response relationship for breast cancer and brain tumors.
开展了一项病例对照研究，以调查1920年至1959年间18个月以下因皮肤血管瘤接受照射的14647名个体（33%为男性，67%为女性）中吸收剂量与癌症风险之间的可能关联。病例包括56例乳腺癌（55名患者）、14例甲状腺癌、16例脑肿瘤以及8例骨和软组织肿瘤。每个病例匹配4名对照。对照按性别、治疗时年龄、治疗方式和治疗年份进行匹配。吸收剂量分为三个暴露组，低于0.1 Gy、0.1 - 0.4 Gy以及大于或等于0.5 Gy，并以最低暴露组为参照估计比值比（OR）。甲状腺癌（OR：1.0；4.8；4.3）以及骨和软组织肿瘤（OR：1.0；1.6；19.5）呈现出具有统计学意义的正剂量反应关系。对于乳腺癌和脑肿瘤，未发现显著的剂量反应关系。甲状腺癌、骨和软组织肿瘤、乳腺癌以及脑肿瘤病例中肿瘤部位的吸收剂量中位数分别为0.2 Gy、0.3 Gy、0.03 Gy和0.04 Gy。该剂量可能过低，以至于无法检测到乳腺癌和脑肿瘤的任何剂量反应关系。
