Lundell M, Holm L E
Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden.
Acta Oncol. 1995;34(6):727-34. doi: 10.3109/02841869509127179.
Cancer incidence was studied in 14,351 subjects exposed to ionizing radiation for skin hemangioma at the Radiumhemmet, 1920-1959. Record-linkage was done with the Swedish Cancer Registry for the period 1958-1986. After a mean follow-up of 39 years, 300 cancers were observed and the standardized incidence ratio (SIR) was 1.11 (95% confidence interval (CI) 0.99-1.24). The absorbed dose to different organs varied from < 0.01 Gy to > 40 Gy. The thyroid cancer incidence was significantly increased (SIR = 2.28; 95% CI 1.33-3.65) and for cancer of the breast SIR was 1.24 (95% CI 0.98-1.54). Regarding pancreatic cancer and tumors of the endocrine glands the statistically significantly increased SIRs were based on a small number of cases and might therefore only be a coincidence. No confirmed increased incidence could be established for other cancer sites.
1920年至1959年期间，在镭疗医院，对14351名因皮肤血管瘤接受电离辐射的受试者的癌症发病率进行了研究。1958年至1986年期间，与瑞典癌症登记处进行了记录链接。经过平均39年的随访，观察到300例癌症，标准化发病率（SIR）为1.11（95%置信区间（CI）0.99 - 1.24）。不同器官的吸收剂量从<0.01 Gy到>40 Gy不等。甲状腺癌发病率显著增加（SIR = 2.28；95% CI 1.33 - 3.65），乳腺癌的SIR为1.24（95% CI 0.98 - 1.54）。关于胰腺癌和内分泌腺肿瘤，统计学上显著增加的SIR是基于少数病例，因此可能只是巧合。其他癌症部位未证实发病率增加。
