HTLV-2 APH-2 的表达与前病毒载量相关，但 APH-2 并不促进淋巴细胞增多。
HTLV-2 APH-2 expression is correlated with proviral load but APH-2 does not promote lymphocytosis.
机构信息
Equipe Oncogenèse Rétrovirale, INSERM-U758 Virologie Humaine, France.
出版信息
J Infect Dis. 2012 Jan 1;205(1):82-6. doi: 10.1093/infdis/jir708. Epub 2011 Nov 7.
Abstract
We recently discovered the antisense protein of human T-cell leukemia virus (HTLV) type 2 (APH-2), whose messenger RNA is encoded by the antisense strand of the HTLV-2 genome. We quantified proviral load, level of tax, and APH-2 in a series of blood samples obtained from a cohort of HTLV-2 carriers. We determined whether APH-2 promotes cell proliferation. APH-2 was detectable in most samples tested and was correlated with proviral load. APH-2 levels were not correlated with lymphocyte count in vivo, consistent with the inability of APH-2 to promote cell proliferation in vitro. APH-2 does not promote cell proliferation and does not cause lymphocytosis.
摘要
我们最近发现了人类 T 细胞白血病病毒 2 型（HTLV-2）的反义蛋白（APH-2），其信使 RNA 由 HTLV-2 基因组的反义链编码。我们对一系列来自 HTLV-2 携带者队列的血液样本中的前病毒载量、tax 水平和 APH-2 进行了定量检测。我们确定了 APH-2 是否促进细胞增殖。在大多数测试样本中均可检测到 APH-2，且与前病毒载量相关。APH-2 水平与体内淋巴细胞计数无关，这与 APH-2 无法在体外促进细胞增殖一致。APH-2 不会促进细胞增殖，也不会导致淋巴细胞增多。
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2
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3
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Retrovirology. 2009 Feb 19;6:19. doi: 10.1186/1742-4690-6-19.
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J Clin Microbiol. 2009 Apr;47(4):1129-35. doi: 10.1128/JCM.02006-08. Epub 2009 Feb 11.
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