microRNAs 在糖尿病及其心血管并发症中的作用。

Laboratory of Vascular Pathology and Regeneration, Bristol Heart Institute and School of Clinical Science-Regenerative Medicine Section, University of Bristol, Bristol Royal Infirmary, Marlborough Street, BS2 8HW Bristol, UK.

Cardiovasc Res. 2012 Mar 15;93(4):583-93. doi: 10.1093/cvr/cvr300. Epub 2011 Nov 7.

Diabetes is the most common metabolic disorder and is recognized as one of the most important health threats of our time. MicroRNAs (miRNAs) are a novel group of non-coding small RNAs that have been implicated in a variety of physiological processes, including glucose homeostasis. Recent research has suggested that miRNAs play a critical role in the pathogenesis of diabetes and its related cardiovascular complications. This review focuses on the aberrant expression of miRNAs in diabetes and examines their role in the pathogenesis of endothelial dysfunction, cardiovascular disease, and diabetic retinopathy. Furthermore, we discuss the potential role of miRNAs as blood biomarkers and examine the potential of therapeutic interventions targeting miRNAs in diabetes.

糖尿病是最常见的代谢紊乱疾病，被认为是我们这个时代最重要的健康威胁之一。microRNAs（miRNAs）是一类新的非编码小分子 RNA，它们参与了多种生理过程，包括葡萄糖稳态。最近的研究表明，miRNAs 在糖尿病及其相关心血管并发症的发病机制中起着关键作用。本综述重点讨论了 miRNAs 在糖尿病中的异常表达，并研究了它们在血管内皮功能障碍、心血管疾病和糖尿病性视网膜病变发病机制中的作用。此外，我们还讨论了 miRNAs 作为血液生物标志物的潜在作用，并研究了针对糖尿病的 miRNAs 治疗干预的潜力。