Powell J, McConkey C C
Regional Cancer Registry, Queen Elizabeth Medical Centre, Birmingham, UK.
Br J Cancer. 1990 Sep;62(3):440-3. doi: 10.1038/bjc.1990.314.
Data in a regional cancer registry covering a population of 5 million and with an efficiency of registration of over 95% have been used to examine incidence trends in oesophageal and gastric carcinoma. In the West Midlands Region of the UK, during the period 1962 to 1981 the age standardised incidence of gastric carcinoma decreased by 20%. However, an analysis by both histological type and detailed site reveals that while the incidence of distal lesions is diminishing, the incidence of adenocarcinoma of the oesophagus and cardia is increasing. The proximal and distal lesions also exhibit marked differences in social class distribution and sex ratio. The results strongly suggest that the aetiological factors involved for cardia and adjoining sites are different from those for pyloric antrum.
一个覆盖500万人口且登记效率超过95%的地区癌症登记处的数据，已被用于研究食管癌和胃癌的发病率趋势。在英国西米德兰兹地区，1962年至1981年期间，胃癌的年龄标准化发病率下降了20%。然而，按组织学类型和详细部位进行的分析显示，虽然远端病变的发病率在下降，但食管和贲门腺癌的发病率却在上升。近端和远端病变在社会阶层分布和性别比例上也存在显著差异。结果有力地表明，贲门及相邻部位所涉及的病因与幽门窦的病因不同。
