Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Toxins (Basel). 2010 Nov;2(11):2490-518. doi: 10.3390/toxins2112490. Epub 2010 Oct 26.
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.
顺铂是一种广泛应用且高效的癌症化疗药物。顺铂使用的一个限制副作用是肾毒性。过去 10 年的研究揭示了许多潜在的细胞机制，这些机制是顺铂诱导的肾细胞死亡的基础。此外，肾脏上皮细胞损伤引起的炎症会放大体内的肾损伤和功能障碍，这一点也变得明显了。这篇综述总结了我们对顺铂肾毒性的理解的最新进展，并讨论了这些进展如何导致更有效的预防。
