人类白细胞抗原（HLA）相关的HIV-1感染易感性。
HLA-associated susceptibility to HIV-1 infection.
作者信息
Fabio G, Scorza R, Lazzarin A, Marchini M, Zarantonello M, D'Arminio A, Marchisio P, Plebani A, Luzzati R, Costigliola P
机构信息
Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.
出版信息
Clin Exp Immunol. 1992 Jan;87(1):20-3. doi: 10.1111/j.1365-2249.1992.tb06407.x.
Abstract
We studied HLA antigen distribution of 50 heterosexual partners of HIV+ drug abusers with more than 1 year of sexual exposure to HIV, 36 children born to seropositive mothers and 61 haemophiliac patients exposed to presumably infectious clotting factor concentrates. B52 and B44 antigens were associated with HIV resistance while B51 was associated with HIV susceptibility. Forty-nine HIV+ drug abusers, spouses of heterosexual partners studied and 25 HIV+ mothers of the children were also typed. DR11 phenotype was associated with infectiousness of HIV+ subjects. Our data suggest that the HLA region controls susceptibility to infection with HIV and infectiousness of HIV+ subjects in different risk groups.
摘要
我们研究了50名与HIV阳性药物滥用者有超过1年性接触的异性伴侣、36名血清反应阳性母亲所生子女以及61名接触过可能具有传染性的凝血因子浓缩物的血友病患者的HLA抗原分布情况。B52和B44抗原与HIV抗性相关，而B51与HIV易感性相关。还对49名HIV阳性药物滥用者、所研究异性伴侣的配偶以及25名子女的HIV阳性母亲进行了分型。DR11表型与HIV阳性受试者的传染性相关。我们的数据表明，HLA区域控制着不同风险群体对HIV感染的易感性以及HIV阳性受试者的传染性。
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本文引用的文献
1
HLA studies in acquired immune deficiency syndrome patients with Kaposi's sarcoma.对患有卡波西肉瘤的获得性免疫缺陷综合征患者的人类白细胞抗原研究。
J Clin Immunol. 1984 May;4(3):242-5. doi: 10.1007/BF00914972.
2
HLA and disease 1982--a survey.HLA与疾病（1982年）——一项调查
Immunol Rev. 1983;70:193-218. doi: 10.1111/j.1600-065x.1983.tb00715.x.
3
Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). IV. Distinct H-2-linked Ir genes control antibody responses to different HBsAg determinants on the same molecule and map to the I-A and I-C subregions.对乙型肝炎表面抗原（HBsAg）免疫应答的遗传调控。IV. 不同的H-2连锁Ir基因控制对同一分子上不同HBsAg决定簇的抗体应答，并定位于I-A和I-C亚区。
J Exp Med. 1984 Jan 1;159(1):41-56. doi: 10.1084/jem.159.1.41.
4
Increased frequency of HLA-DR5 in lymphadenopathy stage of AIDS.艾滋病淋巴结病期HLA - DR5频率增加。
Lancet. 1983 Jul 2;2(8340):51-2. doi: 10.1016/s0140-6736(83)90039-9.
5
Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.同种移植的血清分型。18. 微滴淋巴细胞细胞毒性试验的改进。
Transplantation. 1968 Nov;6(8):913-27. doi: 10.1097/00007890-196811000-00006.
6
HL-A antigens and disease. Statistical and genetical considerations.组织相容性白细胞抗原与疾病。统计学及遗传学考量。
Tissue Antigens. 1974;4(2):95-105. doi: 10.1111/j.1399-0039.1974.tb00230.x.
7
HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia.艾滋病相关持续性全身性淋巴结肿大（PGL）和血小板减少症患者的人类白细胞抗原A、B和DR抗原频率。
Tissue Antigens. 1987 Jan;29(1):60-2. doi: 10.1111/j.1399-0039.1987.tb01550.x.
8
9
Structure of the human class I histocompatibility antigen, HLA-A2.人类I类组织相容性抗原HLA - A2的结构
Nature. 1987;329(6139):506-12. doi: 10.1038/329506a0.
10
HLA-associated susceptibility to AIDS: HLA B35 is a major risk factor for Italian HIV-infected intravenous drug addicts.HLA与艾滋病易感性：HLA B35是意大利感染HIV的静脉吸毒者的主要危险因素。
Hum Immunol. 1988 Jun;22(2):73-9. doi: 10.1016/0198-8859(88)90038-9.
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