高风险痣表型个体的黑色素瘤风险分层 - 一项初步研究。
Melanoma risk stratification of individuals with a high-risk naevus phenotype - A pilot study.
机构信息
Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Memorial Sloan Kettering Cancer Center, New York, New York, USA.
出版信息
Australas J Dermatol. 2019 Nov;60(4):e292-e297. doi: 10.1111/ajd.13039. Epub 2019 Apr 2.
BACKGROUND/OBJECTIVES: High a naevus counts and atypical naevi are risk factors for cutaneous melanoma. However, many individuals with a high-risk naevus phenotype do not develop melanoma. In this study, we describe the clinical and dermoscopic attributes of naevi associated with melanoma in a high-risk naevus phenotype population.
METHODS
This single-centre, hospital-based case-control study included 54 prospectively enrolled adult patients ≥18 years old with a high-risk naevus phenotype (18 cases with a history of melanoma and 36 age- and gender-matched controls without a history of melanoma). We analysed clinical and dermoscopic images of the 20 largest naevi for each participant.
RESULTS
Cases had a higher mean age than controls (48.2 vs. 39.1 years, P = 0.007) but there was no difference in the male-to-female ratio between groups. Nearly, all participants (97%) were Fitzpatrick skin type II or III. Naevi in cases were more likely to be truncal, (72.6% vs. 53.6%, P = 0.01), particularly anterior truncal, (29.2% vs. 14.4%, P < 0.001) and larger than 8 mm (17.4% vs. 7.8%%, P = 0.01) compared to controls. CASH score of naevi did not differ between groups. Naevi in cases were more likely to have a multicomponent dermoscopic pattern than in controls (18.4% vs. 12.6%, P = 0.02).
CONCLUSION
Larger naevi, truncal naevi, and naevi, with a multicomponent dermoscopic pattern may be risk factors for melanoma among individuals with a high-risk naevus phenotype. Further studies are needed to validate these findings.
背景/目的：高痣计数和非典型痣是皮肤黑色素瘤的危险因素。然而，许多具有高风险痣表型的个体并不发展为黑色素瘤。在本研究中，我们描述了高风险痣表型人群中与黑色素瘤相关的痣的临床和皮肤镜特征。
方法
这是一项单中心、基于医院的病例对照研究，纳入了 54 名年龄在 18 岁及以上的具有高风险痣表型的前瞻性成年患者（18 例有黑色素瘤病史，36 例年龄和性别匹配的无黑色素瘤病史对照）。我们分析了每位参与者的 20 个最大痣的临床和皮肤镜图像。
结果
病例组的平均年龄高于对照组（48.2 岁比 39.1 岁，P = 0.007），但两组的男女比例无差异。几乎所有参与者（97%）均为 Fitzpatrick 皮肤类型 II 或 III。病例组的痣更可能位于躯干（72.6%比 53.6%，P = 0.01），特别是前躯干（29.2%比 14.4%，P < 0.001），且大于 8mm（17.4%比 7.8%，P = 0.01）。两组的 CASH 评分无差异。病例组的痣更可能具有多成分皮肤镜模式，而对照组则不然（18.4%比 12.6%，P = 0.02）。
结论
较大的痣、躯干痣和具有多成分皮肤镜模式的痣可能是高风险痣表型个体中黑色素瘤的危险因素。需要进一步的研究来验证这些发现。
Zotero 插件