Department of Internal Medicine, University of Tartu, Tartu, Estonia.
J Clin Densitom. 2012 Jan-Mar;15(1):32-8. doi: 10.1016/j.jocd.2011.08.007. Epub 2011 Nov 9.
Sarcopenia has been shown to be a marker of falling; therefore, combining osteopenia and sarcopenia could identify a frailer, higher-fracture-risk population. We aimed to define sarco-osteopenia (SOP) in a population-based healthy young sample using both muscle functional and quantitative parameters and assessing the impact of this definition on health-related quality of life. A population sample of 304 patients aged 25-70 yr was analyzed with a Lunar DPX-IQ dual-energy X-ray absorptiometry machine (GE Healthcare, Pollards Wood, UK), and their health-related quality of life was assessed with the Short-Form-36 (SF-36) questionnaire. SOP was defined as bone mineral density (BMD) -1 standard deviation (SD) and height-adjusted appendicular muscle mass -2 SD and/or grip strength -2 SD less than the mean values of 77 young individuals in the population sample (age: 25-39 yr). Our proposed SOP definition identifies 3-9% of the population older than 40 yr as sarco-osteopenic. These individuals also show markedly lower scores in the role-physical (p=0.01), vitality (p=0.03), and role-emotional (p=0.02) subscales of the SF-36 questionnaire. No difference in the quality of life was observed between osteopenic individuals and those with normal BMD. The new definition identifies a population with significant decrements in health-related quality of life.
肌肉减少性骨质疏松症（SOP）定义为骨密度（BMD）降低 1 个标准差（SD），身高调整后的四肢肌肉质量降低 2 SD，握力降低 2 SD，均低于人群样本中 77 名年轻个体（年龄：25-39 岁）的平均值。我们提出的 SOP 定义将 3-9%的 40 岁以上人群定义为肌肉减少性骨质疏松症。这些个体在 SF-36 问卷的身体角色（p=0.01）、活力（p=0.03）和情绪角色（p=0.02）子量表中的得分明显较低。骨质疏松个体与骨密度正常个体的生活质量无差异。新定义确定了一个生活质量显著下降的人群。
