Lucassen Eliane A, de Mutsert Renée, le Cessie Saskia, Appelman-Dijkstra Natasha M, Rosendaal Frits R, van Heemst Diana, den Heijer Martin, Biermasz Nienke R
Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden, Leiden University Medical Center, The Netherlands.
Department of Internal Medicine, The Hague, Medisch Centrum Haaglanden, The Netherlands.
PLoS One. 2017 May 1;12(5):e0176685. doi: 10.1371/journal.pone.0176685. eCollection 2017.
Sleep deprivation has detrimental metabolic consequences. Osteopenia and sarcopenia usually occur together and increase risk of fractures and disease. Results from studies linking sleep parameters to osteopenia or sarcopenia are scarce and inconsistent.
To examine the associations of sleep parameters with osteopenia and sarcopenia, considering the influence of sex and menopause.
DESIGN, SETTING AND PARTICIPANTS: Cross-sectional analysis of 915 participants (45-65 years, 56% women, BMI 26 (range: 18-56) kg/m2) in the Netherlands Epidemiology of Obesity (NEO) study, a population-based cohort study. Sleep duration, quality, and timing were assessed with the Pittsburgh Sleep Quality Index (PSQI); bone mineral density and relative appendicular muscle mass were measured by DXA scans. Linear and logistic regressions were performed to associate sleep parameters to bone mineral density, relative appendicular muscle mass, osteopenia (t-score between -1 and -2.5) and sarcopenia (1 SD below average muscle mass).
After adjustment for confounding factors, one unit increase in PSQI score (OR and 95% CI, 1.09, 1.03-1.14), declined self-rated sleep quality (1.76, 1.03-3.01), sleep latency (1.18, 1.06-1.31), and a one hour later sleep timing (1.51, 1.08-2.11), but not sleep duration (1.05, 0.90-1.23), were associated with osteopenia. PSQI score (1.10, 1.02-1.19) was also associated with sarcopenia; OR's of sleep latency and later mid-sleep time with sarcopenia were 1.14 (0.99-1.31) and 1.54 (0.91-2.61), respectively. Associations were somewhat stronger in women and varied per menopausal status.
These results suggest that decreased sleep quality and a later sleep timing are risk factors for osteopenia and sarcopenia in middle aged individuals.
睡眠剥夺会产生有害的代谢后果。骨质减少和肌肉减少症通常同时出现，并增加骨折和患病风险。将睡眠参数与骨质减少或肌肉减少症联系起来的研究结果很少且不一致。
考虑性别和绝经的影响，研究睡眠参数与骨质减少和肌肉减少症之间的关联。
设计、地点和参与者：对荷兰肥胖流行病学（NEO）研究中的915名参与者（45 - 65岁，56%为女性，体重指数26（范围：18 - 56）kg/m²）进行横断面分析，这是一项基于人群的队列研究。使用匹兹堡睡眠质量指数（PSQI）评估睡眠时长、质量和时间；通过双能X线吸收法扫描测量骨矿物质密度和相对上肢肌肉质量。进行线性和逻辑回归以将睡眠参数与骨矿物质密度、相对上肢肌肉质量、骨质减少（T值在 - 1至 - 2.5之间）和肌肉减少症（低于平均肌肉质量1个标准差）相关联。
在调整混杂因素后，PSQI评分每增加一个单位（比值比及95%置信区间，1.09，1.03 - 1.14）、自我评定睡眠质量下降（1.76，1.03 - 3.01）、睡眠潜伏期（1.18，1.06 - 1.31）以及睡眠时间晚一小时（1.51，1.08 - 2.11），但睡眠时长（1.05，0.90 - 1.23）与骨质减少相关。PSQI评分（1.10，1.02 - 1.19）也与肌肉减少症相关；睡眠潜伏期和睡眠中期时间较晚与肌肉减少症的比值比分别为1.14（0.99 - 1.31）和1.54（0.91 - 2.61）。这些关联在女性中稍强，且因绝经状态而异。
这些结果表明，睡眠质量下降和睡眠时间较晚是中年个体骨质减少和肌肉减少症的危险因素。
