Department of Obstetrics and Gynecology, Long Beach Memorial Medical Center, Long Beach, CA, USA.
Am J Obstet Gynecol. 2011 Sep;205(3):271.e1-6. doi: 10.1016/j.ajog.2011.06.041. Epub 2011 Jun 17.
The purpose of this study was to compare obstetric outcomes and maternal satisfaction in nulliparous women in spontaneous labor who used patient-controlled epidural analgesia (PCEA) vs continuous epidural infusion (CEI).
We conducted a double-masked trial of 270 nulliparous women who were assigned randomly to 3 groups (with a concentration 0.1% bupivacaine and 2 μg/mL fentanyl): group I, CEI-only (10 mL/h); group II, CEI + PCEA (CEI 10 mL/h plus PCEA 10 mL, at 20 minutes); group III, PCEA-only (10 mL, at 20 minutes). A PCEA bolus button was given to each subject. The primary outcome was the dosage of local anesthetic that was used.
The total milligrams of bupivacaine that were used was less in the PCEA-only group compared with CEI: group I. 74.8 ± 36 mg; group II, 97.3 ± 53 mg; group III, 52.4 ± 42 mg (P < .001). Pain with pushing, however, was worse in the PCEA-only group. Median satisfaction scores were similar (scale, 0 [best] to 100 [worst]: group I, 0; group II, 0; group III, 0 (P = .23).
PCEA results in less anesthetic used, and maternal satisfaction remains high without a continuous infusion. Pain with pushing, however, was worse with the PCEA alone.
本研究旨在比较自然分娩的初产妇使用患者自控硬膜外镇痛(PCEA)与持续硬膜外输注(CEI)的产科结局和产妇满意度。
我们进行了一项双盲试验,纳入了 270 名初产妇,随机分为 3 组(布比卡因浓度 0.1%,芬太尼 2μg/mL):I 组,仅 CEI(10mL/h);II 组,CEI+PCEA(CEI 10mL/h 加 PCEA 10mL,20 分钟);III 组,仅 PCEA(20 分钟时 10mL)。每位受试者均给予 PCEA 推注按钮。主要结局指标是使用的局部麻醉药剂量。
与 CEI 相比,仅 PCEA 组使用的布比卡因总量较少:I 组 74.8±36mg;II 组 97.3±53mg;III 组 52.4±42mg(P<0.001)。然而,仅 PCEA 组在推注时疼痛更严重。中位数满意度评分相似(评分范围 0[最佳]至 100[最差]:I 组 0;II 组 0;III 组 0(P=0.23)。
PCEA 可减少麻醉药用量,且无需持续输注即可保持较高的产妇满意度。然而,仅 PCEA 会导致推注时疼痛更严重。