Nestle Research Center Beijing, No. 5 DiJin Road, Beijing, China.
Hypertens Res. 2012 Apr;35(4):370-4. doi: 10.1038/hr.2011.195. Epub 2011 Nov 10.
Chlorogenic acids (CGAs) are potent antioxidants found in certain foods and drinks, most notably in coffee. In recent years, basic and clinical investigations have implied that the consumption of chlorogenic acid can have an anti-hypertension effect. Mechanistically, the metabolites of CGAs attenuate oxidative stress (reactive oxygen species), which leads to the benefit of blood-pressure reduction through improved endothelial function and nitric oxide bioavailability in the arterial vasculature. This review article highlights the physiological and biochemical findings on this subject and highlights some remaining issues that merit further scientific and clinical exploration. In the framework of lifestyle modification for the management of cardiovascular risk factors, the dietary consumption of CGAs may hold promise for providing a non-pharmacological approach for the prevention and treatment of high blood pressure.
绿原酸（CGAs）是存在于某些食物和饮料中的强效抗氧化剂，在咖啡中尤为突出。近年来，基础和临床研究表明，绿原酸的摄入可能具有降血压作用。从机制上讲，CGAs 的代谢产物可减轻氧化应激（活性氧），从而通过改善动脉血管内皮功能和一氧化氮生物利用度来降低血压。本文综述了该主题的生理生化研究结果，并强调了一些仍需进一步科学和临床探索的问题。在通过生活方式改变来管理心血管危险因素的框架内，CGAs 的饮食摄入可能为预防和治疗高血压提供一种非药物治疗方法。
