Nagaoka S, Akashi R
Basic Research Laboratories, Toray Industries, Inc., Kanagawa, Japan.
Biomaterials. 1990 Aug;11(6):419-24. doi: 10.1016/0142-9612(90)90098-b.
A hydrophilic polymer surface was developed exhibiting excellent low frictional property, namely slipperiness, when in contact with water or physiological fluid due to the reaction of epoxy-containing poly(vinyl pyrrolidone) with the polyamino compound formed on the surface of the substrate. Epoxy-containing poly(vinyl pyrrolidone) was obtained by the copolymerization of vinyl pyrrolidone as a hydrophilic component, glycidyl acrylate as a binding component to the substrate, and vinyl acetate to preserve the strength of the coating layer. The surface friction coefficient depends on the molecular weight of the coated hydrophilic copolymer. It was demonstrated that a molecular weight of 400,000 or more is essential to achieve excellent low surface friction. Using rabbit models, polyurethane catheters, both with and without the hydrophilic low friction coating, were evaluated for surface friction coefficient and blood compatibility. As a result, in the case of coated catheters, no lesions of the intima of the blood vessels and no thrombus formations on the surfaces of the catheters were observed. However, the non-coated catheters injured the intima of the blood vessels and severe thrombus formation was found on their surfaces.
通过含环氧基的聚乙烯吡咯烷酮与在基材表面形成的聚氨基化合物反应，开发出一种亲水性聚合物表面，当与水或生理流体接触时，该表面表现出优异的低摩擦性能，即滑爽性。含环氧基的聚乙烯吡咯烷酮是通过将作为亲水性组分的乙烯基吡咯烷酮、作为与基材结合组分的丙烯酸缩水甘油酯以及用于保持涂层强度的醋酸乙烯酯进行共聚而获得的。表面摩擦系数取决于涂覆的亲水性共聚物的分子量。结果表明，分子量达到400,000或更高对于实现优异的低表面摩擦至关重要。使用兔模型，对带有和亲水性低摩擦涂层的聚氨酯导管的表面摩擦系数和血液相容性进行了评估。结果，在涂覆导管的情况下，未观察到血管内膜损伤，且导管表面未形成血栓。然而，未涂覆的导管损伤了血管内膜，并且在其表面发现了严重的血栓形成。
