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二异丙基硫脲金属配合物的合成、表征及抗菌研究。

Metal complexes of diisopropylthiourea: synthesis, characterization and antibacterial studies.

机构信息

Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa; E-Mail:

出版信息

Int J Mol Sci. 2011;12(10):7186-98. doi: 10.3390/ijms12107186. Epub 2011 Oct 21.

Abstract

Co(II), Cu(II), Zn(II) and Fe(III) complexes of diisopropylthiourea have been synthesized and characterized by elemental analyses, molar conductivity, magnetic susceptibility, FTIR and electronic spectroscopy. The compounds are non-electrolytes in solution and spectroscopic data of the complexes are consistent with 4-coordinate geometry for the metal(II) complexes and six coordinate octahedral for Fe(III) complex. The complexes were screened for their antibacterial activities against six bacteria: Escherichia coli, Pseudomonas auriginosa, Klebsiella pneumoniae, Bacillus cereus, Staphylococcus aureus and Bacillus pumilus. The complexes showed varied antibacterial activities and their minimum inhibitory concentrations (MICs) were determined.

摘要

二异丙基硫脲的 Co(II)、Cu(II)、Zn(II) 和 Fe(III) 配合物已通过元素分析、摩尔电导率、磁化率、FTIR 和电子光谱进行了合成和表征。这些化合物在溶液中为非电解质,配合物的光谱数据与金属(II)配合物的 4 配位几何构型和 Fe(III)配合物的六配位八面体构型一致。这些配合物已针对六种细菌:大肠杆菌、铜绿假单胞菌、肺炎克雷伯菌、蜡状芽孢杆菌、金黄色葡萄球菌和短小芽孢杆菌进行了抗菌活性筛选。这些配合物表现出不同的抗菌活性,并确定了它们的最小抑菌浓度(MIC)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd2/3211032/44f63b5f6e36/ijms-12-07186f1.jpg

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