Verhoef Jan, Fluit Ad
Eijkman-Winkler Center for Medical Microbiology, Infectious Diseases and Inflammation, University Medical Center, Utrecht, Heidelberglaan 100, Rm. G04.614, 3584 CX Utrecht, The Netherlands.
Biochem Pharmacol. 2006 Mar 30;71(7):1036-41. doi: 10.1016/j.bcp.2005.10.013. Epub 2005 Nov 10.
Today, antibiotic resistance is becoming a major healthcare concern. As global travel increases, more antibiotic-resistant bacteria will be disseminated from one country to another, thereby imposing a problem worldwide. Since the development of resistance is an evolutionary process, constant surveillance is needed to gain insight into the problem and surveillance studies needed to document the spread of antibiotic resistance. The basic objectives of surveillance studies in antimicrobial resistance are: to determine the level of resistance in a particular geographical area; to monitor changes in the level of resistance and make this information available to therapeutic policy-makers, as well as to detect new mechanisms of resistance for use as early warning signs; to study how such resistance develops, persists and spreads, and to monitor interventions. Although, surveillance provides the smoking gun for emergence of antibiotic resistance, improvement of the system is necessary and may be achieved through enhanced information technology and diagnostic tools.
如今，抗生素耐药性正成为医疗保健领域的一大担忧。随着全球旅行的增加，更多具有抗生素耐药性的细菌将从一个国家传播到另一个国家，从而在全球范围内引发问题。由于耐药性的产生是一个进化过程，因此需要持续监测以深入了解该问题，并且需要开展监测研究来记录抗生素耐药性的传播情况。抗菌药物耐药性监测研究的基本目标是：确定特定地理区域内的耐药水平；监测耐药水平的变化，并将这些信息提供给治疗政策制定者，同时检测新的耐药机制以作为早期预警信号；研究此类耐药性如何产生、持续存在和传播，并监测干预措施。尽管监测为抗生素耐药性的出现提供了确凿证据，但改进监测系统是必要的，这可以通过增强信息技术和诊断工具来实现。
