Health Protection Agency, Public Health Laboratory, Birmingham, Heart of England NHS Foundation Trust, Bordesley Green East, Birmingham, UK.
Epidemiol Infect. 2012 Sep;140(9):1551-6. doi: 10.1017/S0950268811002251. Epub 2011 Nov 11.
In spring 2009 a new strain of influenza A(H1N1) emerged and caused a worldwide pandemic. This study utilized a large collection of respiratory specimens from suspected cases of influenza A(H1N1) in the UK West Midlands during the pandemic in order to investigate which other respiratory viruses were circulating and whether they played any role in the increased hospitalization rates seen during that period. Study specimens were selected from community and hospitalized patients positive and negative for influenza A(H1N1) and tested by PCR for other respiratory viruses. A number of infections diagnosed as influenza during the summer influenza outbreak were found to be due to other virus infections (most commonly rhinovirus). No statistically significant difference was found between the rates of respiratory virus co-infection with H1N1 in patients from community or hospital locations suggesting underlying factors were likely to be more significant than viral co-infections in determining severity of influenza A(H1N1) disease.
2009 年春季，一种新型甲型 H1N1 流感病毒出现并引发了全球大流行。本研究利用英国西米德兰兹地区大流行期间大量疑似甲型 H1N1 流感呼吸道标本，调查在此期间住院率升高时哪些其他呼吸道病毒在流行以及它们是否发挥了作用。研究标本选自社区和住院的甲型 H1N1 流感阳性和阴性患者，并通过 PCR 检测其他呼吸道病毒。在夏季流感爆发期间被诊断为流感的一些病例实际上是由其他病毒感染引起的（最常见的是鼻病毒）。在社区或医院就诊的 H1N1 患者中，呼吸道病毒合并感染的比率没有统计学差异，这表明在确定甲型 H1N1 流感疾病的严重程度方面，潜在因素可能比病毒合并感染更为重要。
