European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Nucleic Acids Res. 2012 Jan;40(Database issue):D901-6. doi: 10.1093/nar/gkr986. Epub 2011 Nov 10.
OGEE is an Online GEne Essentiality database. Its main purpose is to enhance our understanding of the essentiality of genes. This is achieved by collecting not only experimentally tested essential and non-essential genes, but also associated gene features such as expression profiles, duplication status, conservation across species, evolutionary origins and involvement in embryonic development. We focus on large-scale experiments and complement our data with text-mining results. Genes are organized into data sets according to their sources. Genes with variable essentiality status across data sets are tagged as conditionally essential, highlighting the complex interplay between gene functions and environments. Linked tools allow the user to compare gene essentiality among different gene groups, or compare features of essential genes to non-essential genes, and visualize the results. OGEE is freely available at http://ogeedb.embl.de.
OGEE 是一个在线基因必需性数据库。它的主要目的是增强我们对基因必需性的理解。这是通过收集不仅经过实验测试的必需和非必需基因，还收集相关的基因特征来实现的，如表达谱、复制状态、物种间的保守性、进化起源和胚胎发育的参与。我们专注于大规模实验，并以文本挖掘结果作为补充。基因根据其来源组织成数据集。在数据集之间具有可变必需性状态的基因被标记为条件必需性，突出了基因功能和环境之间的复杂相互作用。链接的工具允许用户在不同的基因组之间比较基因必需性，或比较必需基因和非必需基因的特征，并可视化结果。OGEE 可在 http://ogeedb.embl.de 免费获得。
