金介导的通过三组分偶联反应的寡糖双官能修饰。
Gold-mediated bifunctional modification of oligosaccharides via a three-component coupling reaction.
机构信息
State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
出版信息
Org Biomol Chem. 2012 Feb 7;10(5):925-30. doi: 10.1039/c1ob06429k. Epub 2011 Nov 10.
PMID:22076205
Abstract
An efficient modular approach for single-site incorporation of two independent functionalities (amines and alkynes) into aldehyde-containing oligosaccharides concurrently by using a one-pot gold-mediated three-component coupling reaction in aqueous medium under mild conditions has been developed.
摘要
发展了一种高效的模块化方法，可在温和条件下，在水相介质中通过一锅金介导的三组分偶联反应，同时将两种独立的官能团（胺和炔）高效地、单一位点地引入到含醛的寡糖中。
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