Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
Hum Exp Toxicol. 2012 Apr;31(4):397-404. doi: 10.1177/0960327111426583. Epub 2011 Nov 10.
Acute pancreatitis is a potentially fatal disease with no known cure. The initial events in acute pancreatitis may occur within the acinar cells. We examined the effect of sesamol on (i) a cerulein-induced pancreatic acinar cancer cell line, AR42J, and (ii) cerulein-induced experimental acute pancreatitis in rats. Sesamol inhibited amylase activity and increased cell survival. It also inhibited medium lipid peroxidation and 8-hydroxydeoxyguanosine in AR42J cells compared with the cerulein-alone groups. In addition, in cerulein-treated rats, sesamol inhibited serum amylase and lipase levels, pancreatic edema, and lipid peroxidation, but it increased pancreatic glutathione and nitric oxide levels. Thus, we hypothesize that sesamol attenuates cerulein-induced experimental acute pancreatitis by inhibiting the pancreatic acinar cell death associated with oxidative stress in rats.
急性胰腺炎是一种潜在致命的疾病，目前尚无已知的治愈方法。急性胰腺炎的初始事件可能发生在腺泡细胞内。我们研究了芝麻酚对（i）一种 cerulein 诱导的胰腺腺泡癌细胞系 AR42J 和（ii）cerulein 诱导的大鼠实验性急性胰腺炎的影响。芝麻酚抑制淀粉酶活性并增加细胞存活率。与单独使用 cerulein 的组相比，它还抑制了 AR42J 细胞中的介质脂质过氧化和 8-羟基脱氧鸟苷。此外，在 cerulein 处理的大鼠中，芝麻酚抑制血清淀粉酶和脂肪酶水平、胰腺水肿和脂质过氧化，但增加胰腺谷胱甘肽和一氧化氮水平。因此，我们假设芝麻酚通过抑制与大鼠氧化应激相关的胰腺腺泡细胞死亡来减轻 cerulein 诱导的实验性急性胰腺炎。
