Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran ; Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Basic Med Sci. 2014 Feb;17(2):100-7.
OBJECTIVE(S): A growing interest has recently been attracted towards the identification of plant-based medications including those with protective effects against cognitive impairment. Sesamol has shown promising antioxidant and neuroprotective effects, therefore, we aimed to evaluate its therapeutic potential in epilepsy which is commonly associated with oxidative stress and cognitive impairment.
Male Wistar rats received pentylenetetrazole (PTZ) (30 mg/kg, IP) once every other day until the development of kindling, i.e., the occurrence of stage 5 of seizures for three consecutive trials. After the completion of kindling procedure, behavioural tests including elevated plus maze and passive avoidance were performed in order to assess learning and memory. Oxidative stress was assessed by estimation of lipid peroxidation and reduced glutathione. The effects of pretreatment with sesamol (10, 20, and 30 mg/kg, IP) against PTZ-induced seizures, cognitive impairment and oxidative stress were investigated.
32.45 ± 1.86 days after treatment with PTZ, kindling was developed that was associated with myoclonic jerks and generalized tonic-clonic seizures. Moreover, PTZ kindling induced a remarkable cognitive impairment and oxidative stress. Sesamol (30 mg/kg) significantly delayed the development of kindling and prevented seizure-induced cognitive impairment and oxidative stress.
Sesamol exerts ameliorative effects in the experimental model of epilepsy. This phytochemical may be considered as a beneficial adjuvant for antiepileptic drugs.
最近人们对植物药的兴趣越来越大，包括那些具有预防认知障碍作用的药物。芝麻酚具有良好的抗氧化和神经保护作用，因此，我们旨在评估其在癫痫中的治疗潜力，癫痫通常与氧化应激和认知障碍有关。
雄性 Wistar 大鼠每隔一天接受戊四氮（PTZ）（30mg/kg，腹腔注射）一次，直到点燃发作，即连续三次出现 5 期癫痫发作。在完成点燃程序后，进行行为测试，包括高架十字迷宫和被动回避，以评估学习和记忆。通过测定脂质过氧化和还原型谷胱甘肽来评估氧化应激。研究了芝麻酚（10、20 和 30mg/kg，腹腔注射）预处理对 PTZ 诱导的癫痫发作、认知障碍和氧化应激的影响。
PTZ 治疗后 32.45±1.86 天，引发了癫痫发作，伴有肌阵挛性抽搐和全身性强直-阵挛性癫痫发作。此外，PTZ 点燃诱导了明显的认知障碍和氧化应激。芝麻酚（30mg/kg）显著延缓了点燃的发展，并防止了癫痫诱导的认知障碍和氧化应激。
芝麻酚对癫痫实验模型具有改善作用。这种植物化学物质可以被认为是抗癫痫药物的有益辅助药物。
