从石刁柏中提取的一种新的呋甾烷醇皂苷。
A new furostanol saponin from Asparagus cochinchinensis.
机构信息
Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
出版信息
Arch Pharm Res. 2011 Oct;34(10):1587-91. doi: 10.1007/s12272-011-1001-7. Epub 2011 Nov 12.
A new furostanol saponin, (25S)-26-O-β-D-glucopyranosyl-5β-furost-20(22)-en-3β, 15β,26-triol-3-O-[α-L-rhamnopyranosyl-(1-4)]-β-D: -glucopyranoside, namely, aspacochioside D (1) were isolated from Asparagus cochinchinensis (Lour.) Merr, along with three known saponins, aspacochioside C (2), (25S)-5β-spirostan-3β-yl-O-[O-α-L-rhamnopyranosyl-(1-4)]-β-D-glucopyranoside (3), and pseudoprotoneodioscin (4). The structure of 1 was elucidated on the basis of chemical reactions and spectral analysis (IR, GC, ESI-MS, (1)H-NMR, (13)C-NMR, DEPT, HMBC, HMQC and NOESY). The antiproliferative effects of 1-4 were evaluated in a cytotoxicity assay against the human tumor cell line, A549. Compound 2 (Aspacochioside C) exhibited moderate cytotoxicity against A-549, with an IC(50) value of 3.87 μg/mL.
一种新的呋甾烷醇皂苷，（25S）-26-O-β-D-吡喃葡萄糖基-5β-呋甾-20（22）-烯-3β，15β，26-三醇-3-O-[α-L-鼠李吡喃糖基-(1-4)]-β-D：-吡喃葡萄糖苷，即 asparagoside D（1），从天门冬科植物 Asparagus cochinchinensis（Lour.）Merr 中分离得到，此外还有三种已知的皂苷，asparagoside C（2），（25S）-5β-螺甾烷-3β-yl-O-[O-α-L-鼠李吡喃糖基-(1-4)]-β-D-吡喃葡萄糖苷（3）和伪原 neo 薯蓣皂苷（4）。1 的结构是基于化学反应和光谱分析（IR、GC、ESI-MS、（1）H-NMR、（13）C-NMR、DEPT、HMBC、HMQC 和 NOESY）来阐明的。对 1-4 进行了细胞毒性测定，评估了它们对人肿瘤细胞系 A549 的抗增殖作用。化合物 2（asparagoside C）对 A-549 具有中等的细胞毒性，IC50 值为 3.87 μg/mL。
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