天门冬皂苷A-D，来自天门冬根的具有细胞毒性的甾体皂苷。

Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus.

作者信息

Zhou Li-Bo, Chen Tzu-Hsuan, Bastow Kenneth F, Shibano Makio, Lee Kuo-Hsiung, Chen Dao-Feng

机构信息

Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, People's Republic of China.

出版信息

J Nat Prod. 2007 Aug;70(8):1263-7. doi: 10.1021/np070138w. Epub 2007 Jul 13.

DOI:10.1021/np070138w

PMID:17629328

Abstract

Four new steroidal saponins, filiasparosides A-D (1-4), together with known aspafiliosides A (5) and B (6) were isolated from the roots of Asparagus filicinus. The structures of these new compounds were elucidated by detailed spectroscopic study and chemical analysis. Compounds 1-6 were cytotoxic against human lung carcinoma (A549) and breast adenocarcinoma (MCF-7) tumor cell lines with EC(50) values of 2.3-16.8 microg/mL. Compound 3 showed the most potent cytotoxicity, with EC(50) values of 2.3 and 3.0 microg/mL toward A549 and MCF-7 cell lines, respectively.

摘要

从天门冬的根部分离出了四种新的甾体皂苷，即天门冬皂苷A-D（1-4），以及已知的天门冬皂苷A（5）和B（6）。通过详细的光谱研究和化学分析阐明了这些新化合物的结构。化合物1-6对人肺癌（A549）和乳腺腺癌（MCF-7）肿瘤细胞系具有细胞毒性，其半数有效浓度（EC50）值为2.3-16.8微克/毫升。化合物3表现出最强的细胞毒性，对A549和MCF-7细胞系的EC50值分别为2.3和3.0微克/毫升。