Unit of Pathology, Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Messina, Messina, Italy.
Vet Comp Oncol. 2011 Dec;9(4):310-5. doi: 10.1111/j.1476-5829.2011.00277.x. Epub 2011 Jun 22.
Erythropoietin (EPO)-mediated mitogenic and anti-apoptotic effects involve all the cells expressing functional receptors for EPO (EPOR), as demonstrated by in vitro and in vivo studies. EPO shows pleiotropic effects and acts as an endogenous mediator of adaptive tissue response to metabolic stress protecting tissues from different injuries. Recently, the EPO/EPOR complex has been identified in several neoplastic cell lines and solid tumours. In this study, the authors investigated the mast cells (MCs) number, distribution and their immunoreactivity for EPOR in normal, dysplastic and neoplastic canine mammary gland. The results showed that MCs were more numerous in displastic glands compared with normal and neoplastic glands. As far as the EPOR immunoreactivity is concerned, we did not observe MCs reaction on cancer, in contrast with previously published data where epithelium of neoplastic gland showed an increase in EPOR expression along with the neoplastic progression. Overall, our results might be suggestive for MCs role in oncogenesis and offer new insight regarding to the expression of EPOR in mammary gland cancer in dog.
促红细胞生成素 (EPO) 介导的有丝分裂和抗细胞凋亡作用涉及所有表达功能性 EPO 受体 (EPOR) 的细胞，这已通过体外和体内研究得到证实。EPO 具有多种作用，是对代谢应激的适应性组织反应的内源性介质，可保护组织免受各种损伤。最近，EPO/EPOR 复合物已在多种肿瘤细胞系和实体瘤中被鉴定出来。在这项研究中，作者研究了正常、发育不良和肿瘤犬乳腺中的肥大细胞 (MC) 数量、分布及其对 EPOR 的免疫反应性。结果表明，与正常和肿瘤腺体相比，发育不良的腺体中 MC 数量更多。就 EPOR 免疫反应性而言，我们没有观察到 MC 对癌症的反应，这与之前发表的数据相反，其中肿瘤腺体的上皮随着肿瘤的进展显示出 EPOR 表达的增加。总的来说，我们的结果可能提示 MC 在肿瘤发生中的作用，并为狗乳腺肿瘤中 EPOR 的表达提供新的见解。
