Department of Molecular and Cell Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya City 467-8601, Japan.
Genes Cells. 2012 Jan;17(1):11-27. doi: 10.1111/j.1365-2443.2011.01564.x. Epub 2011 Nov 13.
MicroRNAs (miRNAs) are endogenous single-stranded, 22-nt (nucleotide) RNAs which complement mRNA to initiate post-transcriptional regulation. This review presents updates and evaluations of the public domain resources available for miRNA identification and target prediction toward their utilization in the biomedical research approach. This study discusses the basic principles of miRNA computational studies based on the nature and mechanism of action of miRNAs. Furthermore, we have explored fifty-nine current online miRNA tools that can be categorized into three classes in this paper: (i) miRNA identification; (ii) miRNA target prediction; and (iii) specialized miRNA tools.
MicroRNAs (miRNAs) 是内源性的单链、22nt（核苷酸）RNA，与 mRNA 互补以启动转录后调控。本综述介绍了 miRNA 鉴定和靶标预测的公共领域资源的更新和评估，以将其应用于生物医学研究方法中。本研究根据 miRNA 的性质和作用机制讨论了 miRNA 计算研究的基本原则。此外，我们还探讨了 59 种当前可用的在线 miRNA 工具，并将它们在本文中分为三类：（i）miRNA 鉴定；（ii）miRNA 靶标预测；和（iii）专门的 miRNA 工具。
