细胞膜：脂质视角。

Cell membranes: the lipid perspective.

机构信息

Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstraße 108 Dresden, Germany.

出版信息

Structure. 2011 Nov 9;19(11):1543-8. doi: 10.1016/j.str.2011.10.010.

DOI:10.1016/j.str.2011.10.010

PMID:22078554

Abstract

Although cell membranes are packed with proteins mingling with lipids, remarkably little is known about how proteins interact with lipids to carry out their function. Novel analytical tools are revealing the astounding diversity of lipids in membranes. The issue is now to understand the cellular functions of this complexity. In this Perspective, we focus on the interface of integral transmembrane proteins and membrane lipids in eukaryotic cells. Clarifying how proteins and lipids interact with each other will be important for unraveling membrane protein structure and function. Progress toward this goal will be promoted by increasing overlap between different fields that have so far operated without much crosstalk.

摘要

尽管细胞膜中充满了与脂质混合的蛋白质，但对于蛋白质如何与脂质相互作用以发挥其功能，人们知之甚少。新的分析工具揭示了膜中脂质的惊人多样性。现在的问题是了解这种复杂性的细胞功能。在本观点中，我们专注于真核细胞中整合跨膜蛋白和膜脂的界面。阐明蛋白质和脂质如何相互作用对于揭示膜蛋白结构和功能将是重要的。通过增加迄今为止没有太多交叉对话的不同领域之间的重叠，将促进朝着这一目标取得进展。