Department of Microbiology and Physiological Systems, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Cell Div. 2011 Nov 11;6:19. doi: 10.1186/1747-1028-6-19.
Regulation of cytoskeletal remodeling is essential for cell cycle transitions. In fission yeast two NDR kinase signaling cascades, MOR and SIN, regulate the actin cytoskeleton to promote polarized growth during interphase and cytokinesis respectively. Our understanding of how these signaling pathways are coordinated to assist transition between the two cell-cycle stages is limited. Here, we review work from our laboratory, which reveals that cross talk between the SIN and MOR pathways is required for inhibition of interphase polarity programs during cytokinesis. Given the conservation of NDR kinase signaling pathways, our results may define general mechanisms by which these pathways are coordinated in higher organisms.
细胞骨架重构的调节对于细胞周期的转变至关重要。在裂殖酵母中，两条 NDR 激酶信号通路（MOR 和 SIN）分别调节肌动蛋白细胞骨架，以促进间期的极化生长和胞质分裂。然而，我们对于这些信号通路如何协调以辅助两个细胞周期阶段之间的转变的理解还很有限。在这里，我们回顾了我们实验室的工作，揭示了 SIN 和 MOR 通路之间的串扰对于在胞质分裂期间抑制间期极性程序是必需的。鉴于 NDR 激酶信号通路的保守性，我们的结果可能定义了这些通路在高等生物中协调的一般机制。
