Tvrdá Eva, Kňažická Zuzana, Bárdos László, Massányi Péter, Lukáč Norbert
Slovak University of Agriculture Department of Animal Physiology, Faculty of Biotechnology and Food Sciences Tr. A. Hlinku 2 94976 Nitra Slovakia.
Acta Vet Hung. 2011 Dec;59(4):465-84. doi: 10.1556/AVet.2011.034.
Oxidative stress is a state related to increased cellular damage caused by oxygen and oxygen-derived free radicals known as reactive oxygen species (ROS). It is a serious condition, as ROS and their metabolites attack DNA, lipids and proteins, alter enzymatic systems and cell signalling pathways, producing irreparable alterations, cell death and necrosis. While small amounts of ROS have been shown to be required for several functions of spermatozoa, their excessive levels can negatively impact the quality of spermatozoa and impair their overall fertilising capacity. These questions have recently attracted the attention of the scientific community; however, research aimed at exploring the role of oxidative stress and antioxidants associated with male fertility is still at its initial stages. This review summarises the current facts available in this field and intends to stimulate interest in basic and clinical research, especially in the development of effective methods for the diagnosis and therapy of semen damage caused by oxidative stress.
氧化应激是一种与细胞损伤增加相关的状态，这种损伤由氧气及被称为活性氧（ROS）的氧衍生自由基引起。这是一种严重状况，因为ROS及其代谢产物会攻击DNA、脂质和蛋白质，改变酶系统和细胞信号通路，产生无法修复的改变、细胞死亡和坏死。虽然已表明精子的几种功能需要少量的ROS，但过量的ROS会对精子质量产生负面影响并损害其整体受精能力。这些问题最近引起了科学界的关注；然而，旨在探索氧化应激和与男性生育相关的抗氧化剂作用的研究仍处于初始阶段。本综述总结了该领域目前已知的事实，并旨在激发对基础和临床研究的兴趣，特别是在开发有效方法以诊断和治疗由氧化应激引起的精液损伤方面。
