Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, SE-90187 Umeå, Sweden.
Curr Opin Plant Biol. 2012 Feb;15(1):31-7. doi: 10.1016/j.pbi.2011.10.010. Epub 2011 Nov 11.
Epidermal hairs of Arabidopsis thaliana emerge in regular spacing patterns providing excellent model systems for studies of biological pattern formation. A number of root-hair and leaf-trichome patterning mutants and tools for cell-specific and tissue-specific manipulation of patterning protein activities have been combined in cycles of experimentation and mathematical modelling. These approaches have provided insight into molecular mechanisms of epidermal patterning. During the last two years, endoreplication has, unexpectedly, been found to control cell-fate maintenance during trichome patterning. New genetic interactions between a downstream, positive transcriptional regulator and lateral inhibitors of trichome or non-root-hair fate specification have been uncovered. A lateral inhibitor and a new positive regulator have been identified as major loci affecting trichome patterning in natural Arabidopsis populations. Finally, factors that modify root-hair patterning from the underlying cell layer have been discovered.
拟南芥的表皮毛以规则的间隔模式出现，为研究生物模式形成提供了极好的模型系统。已经将许多根毛和叶毛的模式形成突变体以及用于对模式形成蛋白活性进行细胞特异性和组织特异性操作的工具结合在实验和数学建模的循环中。这些方法为表皮模式形成的分子机制提供了深入了解。在过去的两年中，出乎意料地发现内复制控制着毛状体模式形成过程中的细胞命运维持。已经发现了下游正向转录调节剂与毛状体或非根毛命运特化的侧向抑制剂之间的新遗传相互作用。已经确定一个侧向抑制剂和一个新的正调控因子是影响拟南芥自然种群毛状体模式形成的主要基因座。最后，已经发现了从下伏细胞层修饰根毛模式形成的因子。
