FRA16B在外周血淋巴细胞和骨髓细胞中的差异表达。

Differential expression of FRA16B in peripheral lymphocytes and bone marrow cells.

作者信息

Zollino M, Genuardi M, Neri G

机构信息

Istituto di Genetica Umana, Facoltà di Medicina e Chirugia, Università Cattolica del Sacro Cuore, Rome, Italy.

出版信息

Cancer Genet Cytogenet. 1990 Oct 15;49(2):229-33. doi: 10.1016/0165-4608(90)90146-2.

DOI:10.1016/0165-4608(90)90146-2

PMID:2208058

Abstract

Expression of the rare fragile site FRA16B in chromosome band 16q22 was studied in bone marrow (BM) cells and peripheral blood lymphocytes (PBLs) from three unrelated subjects. Although FRA16B was detected only in PBLs from two healthy subjects who had been previously treated for non-Hodgkin's lymphoma (NHL), both cell types displayed FRA16B in a patient with chronic myelomonocytic leukemia (CMMoL). This variability in expression could be related to differences in the proliferative status of the cell populations or to differences in gene activity in the fragile site region.

摘要

对来自三名无亲缘关系个体的骨髓（BM）细胞和外周血淋巴细胞（PBL）中16号染色体16q22区域罕见脆性位点FRA16B的表达情况进行了研究。虽然仅在两名曾接受过非霍奇金淋巴瘤（NHL）治疗的健康受试者的PBL中检测到FRA16B，但在一名慢性粒单核细胞白血病（CMMoL）患者的两种细胞类型中均显示有FRA16B。这种表达的变异性可能与细胞群体增殖状态的差异或脆性位点区域基因活性的差异有关。