Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Retina. 2012 Apr;32(4):814-25. doi: 10.1097/IAE.0b013e3182278c41.
To report the fundus autofluorescence characteristics in serpiginouslike choroiditis.
Twenty-nine patients with presumed tubercular serpiginouslike choroiditis between November 2008 and January 2010 underwent fundus autofluorescence imaging during the acute stage and at regular intervals till the lesions healed. All patients received antitubercular therapy with oral corticosteroids. The autofluorescence images were compared with color fundus photography and fundus fluorescein angiography. The main outcome measure was fundus autofluorescence characteristics of lesions during the course of the disease.
The pattern of fundus autofluorescence changed as the lesions evolved from the acute to the healed stage. In acute stage, the lesions showed an ill-defined halo of increased autofluorescence (hyperautofluorescence), giving it a diffuse, amorphous appearance (Stage I, acute). As the lesions began to heal, a thin rim of decreased autofluorescence (hypoautofluorescence) surrounded the lesion, defining its edges. The lesions showed predominantly hyperautofluorescence with stippled pattern (Stage II, subacute). With further healing, the hypoautofluorescence progressed and the lesion appeared predominantly hypoautofluorescent with stippled pattern (Stage III, nearly resolved). On complete healing, the lesions became uniformly hypoautofluorescent (Stage IV, completely resolved).
Fundus autofluorescence highlighted the areas of disease activity and was a quick imaging tool for monitoring the course of lesions in serpiginouslike choroiditis.
报道匐行性脉络膜炎的眼底自发荧光特征。
2008 年 11 月至 2010 年 1 月期间，我们对 29 例疑似结核匐行性脉络膜炎患者进行了眼底自发荧光成像检查，在疾病的急性期和定期随访直至病变愈合期间进行了眼底自发荧光成像检查。所有患者均接受了口服皮质类固醇的抗结核治疗。将眼底自发荧光图像与眼底彩色照相和眼底荧光血管造影进行比较。主要观察指标是疾病过程中病变的眼底自发荧光特征。
随着病变从急性期向愈合期的演变，眼底自发荧光的模式发生了变化。在急性期，病变呈现出不规则的高自发荧光晕（高自发荧光），呈现出弥漫性、无定形外观（I 期，急性期）。随着病变开始愈合，病变周围出现一圈薄的低自发荧光（低自发荧光），定义了病变的边缘。病变主要呈现出点状高自发荧光（II 期，亚急性期）。随着进一步愈合，低自发荧光进展，病变主要呈现出点状低自发荧光（III 期，接近愈合）。完全愈合后，病变变得均匀低自发荧光（IV 期，完全愈合）。
眼底自发荧光突出了疾病活动的区域，是监测匐行性脉络膜炎病变过程的快速成像工具。
