Kusnír J, Gombitová D
Katedra lekárskej chémie a biochémie, Lekárska fakulta UPJS, Kosice.
Cesk Farm. 1990 Jul;39(5):220-2.
Tobramycin modified with fluorescamin yields fluorescent derivatives with a gradually changed structure and charge composition. Interactions of these drugs with mitochondria were investigated on the basis of the measurement of their inhibitory effect on the respiration (consumption of O2) of the isolated mitochondria. The results were compared with the effects of the original antibiotic agent. The use of the method of fluorescence polarization made it possible to determine the character of interactions. The procedure is a model experiment with possible wider use.
用荧光胺修饰的妥布霉素产生结构和电荷组成逐渐变化的荧光衍生物。基于这些药物对分离线粒体呼吸作用（氧气消耗）的抑制作用测量，研究了它们与线粒体的相互作用。将结果与原始抗生素的作用进行了比较。荧光偏振方法的使用使得确定相互作用的性质成为可能。该程序是一个具有更广泛应用可能性的模型实验。
